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Annie Rune for Mid, Emerald +Patch 13.24
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Let the data do the talking: these are the best runes by win rate for Annie Mid vs All Champions. U.GG takes the guesswork out of Annie runes. LoL Patch 13.24
Let the data do the talking: these are the best runes by win rate for Annie Mid vs All Champions. U.GG takes the guesswork out of Annie runes. LoL Patch 13.24
Pro BuildsFilters
Middle
Emerald +Ranked Solo
Filters
Middle
Emerald +Ranked Solo
Best Annie Runes
52.85% WR (967 Matches)
Domination
Sorcery
Domination
Sorcery
At 52.85% winrate over 967 matches, this specific Mid Annie rune page has worked the best for most players in Emerald + vs
All Champions
.
Annie benefits from the stacking damage stats from 
Eyeball Collection.
The mana and mana regeneration makes 
Manaflow Band a staple Annie rune.
Stat Shards
Take Adaptive Force (1), Adaptive Force (2), and Magic Resist (3) on Annie Mid vs All Champions. Shards should be based on matchup.
1. First slot Adaptive Force grants strong early damage potential and burst for Annie Mid.
2. Adaptive Force is the standard second shard into most matchups.
3. Take Magic Resist third versus magic damage (AP) matchups.